December 2024
Richard, Ellie, Nan and Josephina attended a scientific discussion meeting at the Royal Society to mark 40 years of research on EGFR. Nan and Josephina presented posters and Josephina also gave a talk. We caught up with friends in the kinase field and made some new connections. We look forward to celebrating more scientific milestones!
November 2024
Announcing our UK-Japan BBSRC/JST award! The Bayliss group are part of a team that has won a groundbreaking £1.2 million funding award that sees UK and Japanese universities undertaking cell engineering research which could have a major impact on the treatment of cancer in the future. We are co-leading the Data Driven Multi-scale Engineering of Cell Fate Decisions project (also known as Bioengage). The £1.2 million funding is awarded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the Japan Science and Technology Agency (JST). The UK team includes scientists from the University of Leeds, Imperial College and The Francis Crick Institute, the UK’s flagship biomedical research centre. It is matched by a similar award to our Japanese colleagues, led by Mariko Okada, until recently the director of the renowned Institute for Protein Research at Osaka University, and including scientists from Osaka and Tokyo Universities alongside RIKEN, Japan's largest comprehensive research institute.
August 2024
In August, Richard, Jenny and Isha all presented work on Aurora-A kinase at the FASEB Protein Phosphorylation in Health and Disease in the beautiful setting of Malahide, Ireland. We caught up with old friends, met some of our collaborators in person for the first time, and established several new connections. Researchers presented exciting discoveries relevant to human health and across a broad range of biology. The field of protein phosphorylation is in great shape!
August 2024
We were delighted to host Lauryn Dunn from Sarah Lawrence College, New York as an undergraduate Summer student in June and July. She made some excellent contributions to our studies on EML4-ALK fusions with experimental work on drug treatments and cell imaging, and generated an impressive amount of modelling data on protein-protein interactions. We wish Lauryn well in her future studies!
June 2024
Project student Chelsea wins a prize!
Congratulations to Chelsea Xinyi Yow on winning a Child Health Outcomes Research at Leeds (CHORAL) undergraduate research prize! Chelsea is a talented Biotechnology with Enterprise MBiol student at the University of Leeds. Her project work on N-myc in neuroblastoma will continue in the Bayliss lab next year.
May 2024
Come and meet us at Be Curious!
We are happy to announce that we will be taking part in Be Curious this year. Be Curious is the University of Leeds’ annual family open day. On the 18th May, our campus will be transformed into a hive of free family-friendly activity. Be Curious is a great way for children in Leeds and beyond to have the chance to get hands-on with the research that happens here at the University and show that the University has a place in everyone’s lives.
You can view the full Be Curious programme here.
13 November 2023 Richard hits podcast stardom! This week's episode of the ground-breaking University of Leeds podcast series 'How to Fix...?' features Prof Richard Bayliss alongside Dr David Sebag-Montefiore (Professor of Clinical Oncology, Director of the Leeds Cancer Research Centre) and Dr Pietro Valdastri (Professor and Chair in Robotics & Autonomous Systems). This episode explores what action the University of Leeds is taking to beat cancer. The three amigos discuss issues such as: How do we address this–can we make detection faster? What innovative treatments are being developed to eradicate the disease? And how can research unlock these answers? All seven episodes of the 'How to Fix...?' series are available on Apple Podcasts and Spotify.
September 2023 Dynamic Interactions: fostering collaboration Twenty-four members of the Zeqiraj, Ochi and Bayliss groups took part in a joint away day at Devonshire Hall in Headingley on 22nd September. The programme featured presentations in a variety of formats from team leaders, postdoctoral and postgraduate researchers and technicians. The talks were focussed on our common research interests in molecular structure, protein dynamics, cell signalling relevant to auto-immune diseases, developmental diseases and cancer. A core theme was our innovative approaches to drug discovery that exploit our knowledge of protein structure and dynamics such as molecular glues and protein-protein interaction inhibitors. Alongside this, Research Technician Jordan Liburd provided a summary of our current efforts to recycle and reuse reagents and consumables, and discussed best practices for doing research in an environmentally sustainable way. The teams also played a game of “Technique Bingo” to encourage inter-group collaboration, share knowledge on different research techniques, and shine a spotlight on our varied expertise across the teams. To round off the day, Kate Ashman, the faculty communications manager, led a lively discussion around ideas for communicating our science to different audiences. Special thanks go to Fran Chandler and Eoin Leen for organising the event, and to the staff at Devonshire Hall for looking after us.
8 September 2023 Congratulations to PhD Student Nan Zhang for winning the first poster prize at the 8th Warsaw Conference on Perspectives of Molecular Oncology!
August 2023 The Bayliss lab had many visitors over the summer. Prof Mariko Okada (Director, Institute for Protein Research, Osaka University) delivered a fascinating seminar to the School of Molecular and Cellular Biology. Richard, Josephina and Nan took her to visit Harrogate and RHS Harlow Carr Gardens. We also had a number of students visiting the lab to gain research experience. Jonny Hunt, an undergraduate from the University of Bristol, joined the lab for a very successful 6-week cell biology research project funded by the Biochemical Society. Several 6th formers spent a week with the Bayliss group to learn about the protein crystallography and biochemical techniques that we use in our lab: Daniel Brown (Harrogate Grammar School), Ibrar Mahmood (Abbey Grange School) and Suhayb Ali (Elliott Hudson College).
April 2023 Josephina and Richard went to Seoul, Korea for the last week of March. We visited Jene Choi, our long-term collaborator at the Asan Medical Center, to plan the next phase of our lung cancer project. We also met up with the leadership team of AMC Sciences, an exciting new initiative in drug discovery, and gave talks at the top research institute KIST. A day trip to the nearby city of Chuncheon was another highlight - we met up with a University of Leeds alumnus Prof. Myeong-Hyeon Wang, talked about biopharmaceuticals and discovered the local delicacy Dak-galbi. The cherry was in full blossom everywhere we went!
March 2023 In early March, Matt and Richard travelled to the USA along with our SPiDR colleagues Andy Wilson and Martin Walko. We visited the groups of Eileen Kennedy and Kannan Natarajan at the University of Georgia in Athens to discuss collaborations and explore new approaches in computational and chemical biology. Athens is a beautiful place to visit and is exceptional for its science, food, music and of course college football. Thanks to everyone who looked after us for sharing their time and expertise!
7 May 2022 The Bayliss lab participated in the University’s annual research open event BeCurious 2022 which aims to showcase the world-changing research here at Leeds to the public.Our stand Lucky I.D.P. explained how intrinsically disordered proteins act like a sort of selective “molecular velcro” to recruit partner proteins to particular locations in the cell where they are needed to carry out their functions in a regulated way. The main attraction was our "cellular pond" ball pool filled with a mixture of "protein" balls, in which participants could fish for "interacting proteins" using velcro "I.D.P." fishing lines. This was extremely popular especially with the younger visitors and we received lots of positive feedback!
7 February 2022 We hit a milestone last week - papers #100 and #101 were published! We rarely publish only our own work these days. These two papers are the result of members of each group making major contributions individually and coming together to analyse and interpret the data. Everyone was so open and collaborative in these projects, it was a pleasure to work together. Kudos to the last authors of these papers, Claire Eyers (University of Liverpool) and Jene Choi (Asan Medical Centre), for being driving forces in the projects. Thanks too to the other PIs involved, Patrick Eyers (University of Liverpool) and Andrew Fry (University of Leicester). We enjoy working with you all and look forward to many more papers together in the future. Thank you to Bayliss lab authors on these papers, Matt Batchelor and Josephina Sampson. They are outstanding postdocs who brought new expertise to the group, and share their time and skills generously with others. The group is really thriving thanks to all who make it a team. Their expertise in NMR, molecular simulation and cell biology has enabled our lab’s science to grow in new directions. This, on top of collaboration with other groups, allows us to address different kinds of questions, as exemplified by these two very different papers. One paper used a combined structural mass spec and computational modelling strategy to probe how ligands affect the conformation of Aurora-A kinase and how ligands affect it. We found a high proportion of the protein adopts an open conformation and we need to rethink some of our models of the kinase, regulation etc. We are now taking on the challenge of the awful, joyous complexity of protein conformations & dynamics in other projects too. DOI: 10.1021/jasms.1c00271 The other paper used cell biological approaches such as viability assays and imaging to explore drug combinations in EML4-ALK lung cancer cells. We found that one common EML4-ALK variant is more resistant to a common cancer drug, whereas a second variant is sensitive. We hope this work can be developed towards finding rational combinations of treatments tailored to patients. DOI: 10.3390/cancers14030779 Finally… 100 papers took almost 25 years from start of PI’s PhD (1997) - so look out for another extended update and thread in another quarter-century!